Spray a microfiber cloth with LCD screen cleaner (not regular glass cleaner) and gently wipe the screen and keyboard until clean. To disinfect the device you can use a small amount of disinfectant such as 409 sprayed onto a rag. If using a disinfectant wipe make sure it is not very wet and gently wipe the device. NEVER use disinfectant on the screens, it could permanently mark the screen.